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Specifically, preliminary data suggest that oral administration of excess Mn (15 mg/kg/day, administered orally by gavage for 30 days) affects fecal metabolomics, including decreased levels of fecal butyrate, -tocopherol, and bile acids and increased levels of palmitic acid and bile acids in rat feces, which may partially mediate the effects of Mn in the body (125)

doi: 10.1080/07315724.2004.10719347

How precise do doses need to be

Meanwhile, inflammation and oxidative stress can upregulate the expression of iron carriers and transporters, possibly causing excessive uptake of iron in the renal tubules and consequent iron-induced kidney injury (75)

But expecting a cloth diaper to last 4-6 hours like some disposables claim is usually unrealistic unless you heavily boost it with extra inserts