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In September 2023, FDA placed "Thymosin Beta-4, Fragment (LKKTETQ)," the substance sold as TB-500, on Category 2 of its interim 503A bulk drug substances list, meaning FDA identified significant safety concerns and would not permit licensed compounding pharmacies to use it

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Often paired with weight management programs to complement diet and movement

Exposure to environmental toxins used in industrial applications, including polyaromatic hydrocarbons and polyhalogenated biphenyls, can also trigger thyroid autoimmunity (Zaletel And Gaberscek 2011)

A growing body of preclinical research continues to explore its mechanisms and applications, including emerging work on neuroprotective effects and potential roles in spinal cord injury recovery