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Reiter RJ, Mayo JC, Tan DX, Sainz RM, Alatorre-Jimenez M, Qin L

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It can, however, be debated whether this inflammatory response in the hippocampus is due to the effect of MGO on astrocytes, whether it is an effect of MGO on the brain and BBB, or whether it is an indirect effect of the glycating potency of MGO elsewhere in the body leading to systemic inflammation and impairing affecting other organs besides the brain

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Mild symptoms may improve with conservative care, especially if constipation or straining is the main trigger