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Vitamin B12 Deficiency and the Risk of Anemia in Patients with T2D on Metformin Therapy The MASTERMIND study, published in 2020, analyzed two randomized trials (ADOPT [A Diabetes Outcome Progression Trial] and UKPDS [UK Prospective Diabetes Study]) and an observational cohort study (GoDARTS [Genetics of Diabetes Audit and Research in Tayside Scotland]) to assess the risk of anemia in patients with diabetes treated with metformin [60]