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Intestinal permeability enhancement: structure-activity and structure-toxicity relationships for nonylphenoxypolyoxyethylene surfactant permeability enhancers

Although a thiotemplate mechanisms involving cyclo-trimerization of ready-made D- O -Leu-D-Ala-L- O -Val-L-Val via a thioesterase (TE) domain is proposed for cereulide biosynthesis, the exact mechanism is far from being understood

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