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According to the studies presented above, chemotherapy may induce apoptosis of progenitor cells leading to reduced differentiation to megakaryocytes and platelets, while upstream HSCs can supplement progenitors by self-renewal and differentiation into downstream progenitors

The CONSORT diagram is presented in Fig

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(b) On axial FS T2-WI, a target appearance with central hypointensity and a peripheral high signal intensity rim can be seen (target sign)