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GSTpi regulates VE-cadherin stabilization through promoting S-glutathionylation of Src

doi:10.1016/j.jacadv.2024.101524

Together these data confirm the expectation that active 6-AH analogs can block dimerization and further that dimerization inhibitory potential of an analog translates, at least qualitatively, to its capacity to block HGF-dependent processes

Study size and inclusion of placebo subjects The majority of FIH clinical trials are blinded, placebocontrolled studies with eight to 10 subjects per cohort randomized in a 3:1 or 4:1 ratio such that six to eight subjects receive the active therapy and two subjects receive placebo