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Polyphenols have the potential to suppress the development of cancer cells through various mechanisms, including interfering with the signaling of growth factor receptors and the cell cycle progression, modulating phosphodiesterase, promoting cellular differentiation and cyclooxygenase pathways, and inhibiting cell signaling kinases

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Interestingly, the secretion of HCV dsRNA from the endosome modulates TLR3 activation, thereby moderating viral replication levels and potentially contributing to viral persistence 32