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In short: Your brain isnt brokenits just disconnected

Nature 4 , 298306, doi:10.1038/nrd1695 (2005)

coli and Helicobacter pylori , is one of the major factors contributing to the exacerbation of oral mucosal lesions ( Figure 1 3.2 The influence of imbalance of oral and intestinal microbial homeostasis on oral mucosal diseases Studies have shown that oral ingestion of microbiota may migrate to the digestive tract and trigger a pathogenic immune response ( The interaction between the oral microbiota and the immune system and epithelial barrier has been well discussed in the gut ( Fusobacterium nucleatum and Streptococcus , which aggravates mucosal damage by activating the Th17 pathway and pro-inflammatory factors ( Porphyromonas gingivalis enrichment and Lactobacillus reuteri depletion, which inhibits pathogens and strengthens barrier function by secreting bacteriocin and butyric acid, while lactic acid and hydrogen peroxide produced by Streptococcus salivarius reduce the risk of ulceration by regulating the local microenvironment ( 4 The basic principles, mechanisms and potential of probiotics in the treatment of oral mucosal diseases Probiotics are a group of living microorganisms that provide health benefits to the host when a certain level of intake is achieved

Cysteine peptidases of mammals: their biological roles and potential effects in the oral cavity and other tissues in health and disease

The results of the LFQ proteomics of the patient data are reported in Supplementary Data 2