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In addition, we will discuss whether PDE5 inhibitors could be exploited for therapeutic purpose in cancer, evaluating ongoing clinical trials, summarized in Table 1

Plasma C-reactive protein and endothelin-1 level in patients with chronic obstructive pulmonary disease and pulmonary hypertension

As mentioned above, the virome strongly influences the microbiome, as certain virusessuch as mycoviruses infecting Malassezia spp .can alter fungal physiology and host interactions, thereby affecting pathogenicity and skin health [32, 124]

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