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Hydrogen(H2) treatment for acute erythymatous skin diseases

These metabolic disturbances lead to hepatic lipid accumulation, Kupffer cell activation, and NLRP3 inflammasome signaling

Studies have shown that the NLRP3 inflammasome is also involved in other skin diseases, such as psoriasis, urticaria, and bullous pemphigoid (179)

This SA-induced H 2 O 2 acts as a second messenger, activating defense proteins and systemic acquired resistance (SAR) (Liu et al., 2022)

In 2015, the International Atomic Energy Agency (IAEA) in partnership with the Food and Agriculture Organization of the United Nations (FAO) released the manual of good practice in food irradiation aiming at improving food irradiation practices worldwide, with a focus on developing countries (Roberts, 2016)