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Furthermore, the increment of ROS content along with the oxidative stress markers increase are suggestive of a putative activation of the p38, ERK MAPK signaling pathway (Torres, 2003)
Additionally, as a hydrophilic molecule, DFO has a poor cell permeability and tends to remain in extracellular fluid, which may still limit its efficacy (Hanson et al., 2009
Ovejero-Benito MC, Reolid A, Snchez-Jimnez P, et al
however, large-scale controlled human efficacy data are not yet available
10.1016/j.cbi.2005.12.009 99 WadaT.PenningerJ
