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doi: 10.1016/j.envres.2018.01.035

In a previous study, products of N - and O -dealkylation products of isotonitazene were detected in forensic samples ( The rapid metabolism of nitazenes in hepatic matrices may also have implications for the detection of the unchanged compounds in the urine and other body matrices

Nat Cell Biol (2015) 17(12):155668
After that, monitor response closely, because some patients feel meaningful airway relief while others are too reactive and need more groundwork first
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