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From yeast to human: exploring the comparative biology of methionine restriction in extending eukaryotic life span

MK-677 (ibutamoren): the oral growth hormone secretagogue MK-677 is technically not a peptide but a growth hormone secretagogue that mimics ghrelin signaling to stimulate GH and IGF-1 release

Yagoda et al

Science 316 (5826), 900904

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