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47 A randomized placebo-controlled trial with 101 menopausal participants found a combination of 520 mg black cohosh, 400 mg chaste tree, 100 mg soy isoflavones, and 500 mg evening primrose oil, taken once daily for 12 weeks, improved hot flashes and sweating, sleep problems, mood, and irritability, as well as levels of C-reactive protein (CRP) (a marker of inflammation), LDL-cholesterol, and triglycerides

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No lethal dose has been identified

You may feel a slight pinch or warmth at the injection site, but discomfort is minimal

Second, the study was limited by the small sample size and the short treatment period (4 months)