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Medicine (Baltimore) (2016) 95(1 Suppl 1):S2025

People with mild B12 deficiencies experience changes in B12 effectiveness yet severe deficiencies need extended treatment time or stronger doses to produce noticeable results
The temperature must be maintained between 2-8C (36-46F)

Arterioscler Thromb Vasc Biol 26(12):26142621 Andersson DC et al (2011) Mitochondrial production of reactive oxygen species contributes to the beta-adrenergic stimulation of mouse cardiomycytes

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