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Autonomic nervous system dysfunction (ANSD) is a relevant contributor to some of the clinical features in RTT patients that leads to multiple impairments ranging from anxiety, GI dysfunction, breathing disturbances, peripheral vascular control alteration (19) to sleep issues (3), heart rate variability (HRV) (2022), and increased risk of sudden death (23, 24)

doi:10.1053/gast.2002.30298

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Refining the ammonia hypothesis: a physiology-driven approach to the treatment of hepatic encephalopathy