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Specifically, the only RCT aiming to investigate the BW lowering efficacy of mazdutide in patients without T2D was limited to Chinese patients and referred to different cut offs for the definition of obesity (BMI 28 kg/m 2 ) 49

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Therapeutic peptides are designed to treat specific medical conditions, while synthetic peptides are created to mimic the structure and function of natural peptides

Overactivated fibroblasts drive abnormal fibrosis accumulation to maintain dynamic balance between inflammation and extracellular matrix (ECM) stiffness