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Tyrosine nitration has been identified in at least 50 human diseases and more than 80 conditions modeled in animals, as reviewed recently (476), and these figures are continuously increasing
Moreover, Mn overload contributes to various forms of toxicity through several mechanisms

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In the B16F10 melanoma subcutaneous tumor model, the treatment by the intraperitoneal injection of LY341495 inhibited melanoma growth in C57BL/6J wide-type mice
