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Vitamin B12 is absolutely critical for the synthesis and maintenance of the myelin sheath that protects these delicate nerves

found that supplementation with folic acid (the synthetic form) in girls with Down syndrome may not be as effective as the active form
It was proposed that chelating agents like EDTA, N -hydroxyethylethylenediamine- NN'N' -triacetic acid (Walsh et al., 2003) and to a lesser extent nitrilotriacetic acid (Haque and Russell, 1974) serve as a potentiating agent, as they destabilize the outer membrane and create easier access for other compounds

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