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[3, 4, 8] Neuropsychiatric changes occur in the hepatic porphyrias (ALA-Dehydrase-Deficiency Porphyria, Acute Intermittent Porphyria, Porphyria Cutanea Tarda, Hereditary Coproporphyria and Variegate Porphyria) with excess production of ALA and PBG and there is a somewhat linear relationship between their concentration and the severity and duration of symptoms

Eur J Appl Physiol 111, 925936

doi: 10.1021/tx050217c

[DOI] [PubMed] [Google Scholar] 81.Borahay M.A., Kilic G.S., Yallampalli C., Snyder R.R., Hankins G.D., Al-Hendy A., Boehning D

Taken together, these experiments support the potential clinical applicability of GPX4 inhibitors to eradicate quiescent astrocyte-like tumor cells in human GBM by targeting a mitochondrial vulnerability of this persister-like population which is resistant to standard of care anti-proliferative therapies