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A 2020 systemic review and meta-analysis of 44 randomized controlled trials that included both healthy adults and those with certain health conditions found that L-carnitine supplementation significantly lowered the inflammatory markers C-reactive protein, interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), and malondialdehyde

After the study period, the ALCAR group demonstrated statistically significant improvements in musculoskeletal pain, depression, and overall quality of life compared to the control group