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References Naimi N, Seyedmirzaei H, Hassannejad Z, Soltani Khaboushan A

Later work demonstrated that the combined absence of the p53 target genes encoding the pro-apoptotic BH3-only proteins PUMA and NOXA (and to a lesser extent loss of PUMA alone) rendered lymphoid cells as resistant to DNA damage-inducing agents as loss of p53 itself [8, 9, 22]

International clinical psychopharmacology

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To address these difficult cases, the research team combined the medication, tofacitinib, with narrow band ultraviolet B light therapy