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Carnitine palmitoyltransferase-1 (CPT1) is an enzyme located on the outer mitochondrial membrane that transports long-chain fatty acids into mitochondria for -oxidation, thus controlling the rate of mitochondrial fatty acid oxidation (FAO)

Although histone lactylation has not yet been directly studied in PAH, given that hypoxia is a central pathological factor in PAH and that significant lactate accumulation and M2 macrophage polarization are observed in PAH patients, histone lactylation may contribute to PAH pathogenesis through these mechanisms, promoting pulmonary vascular remodeling and disease progression

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