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Description
In fact, it is almost impossible, unless the methylene group is activated ( i.e ., made more reactive by the influence of neighbouring functional groups)

Over dosage with valproate may result in somnolence, heart block, and deep coma

10.1038/nm.3145 Nat

(R)-BIS[(3-CARBOXY-2-HYDROXYPROPYL) TRIMETHYL AMMONIUM] L-TARTRATE

1993 Mar-Apr;25(2):59-66
