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( F ) Growth assay of HIF-1 and HIF-2 knockdown HCT116 and SW480 cells treated with DMF alone or in combination with FG4592 (100 M)

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As shown in Figure 3E, F, we observed significantly lower exposure of GSH and CYS in the cortex of AHE rats compared to controls, with oral GSH administration of GSH effectively elevating their levels in this region

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