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Redox sensitive targets in hepatocytes: the central role of APE/Ref-1 as a molecular paradigm It is well established that elevated H2O2 levels are produced in different liver disorders4,19 as well as during ethanol methabolism.20,21 The normal liver is provided with very efficient enzymatic and non enzymatic antioxidant systems.22 In particular, Kupffer cells and hepatic stellate cells are potentially more exposed to ROS molecules and it has been well documented that hepatic antioxidant systems are significantly decreased in several chronic liver diseases.22,23 Although the study of the involvement of the classical intracellular ROS molecular scavengers, such as SOD, CAT, GPx, is of fundamental importance in setting up therapeutical approaches toward oxidative-based liver pathologies, understanding of the molecular switches involved in cell oxidative stress response at the genomic level could also provide interesting applications, in particular the identification of the early molecular switches of the redoxbased cellular response

Yet both molecules complement, not compete and in many cases, theyre stronger together

Frequently Asked Questions What is FOXO4-DRI and how does it work

Copper Peptides for Your Skin and Hair Expectations Copper peptides, known for their potential tissue-repairing properties and anti-inflammatory, might play a significant role in hair health [1]

Both compounds appear to reduce inflammation and fibrosis in controlled lab settings