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Description
Sites where urate crystal deposits and tophi typically first develop have relatively low core temperature, which decreases urate solubility and a connective tissue matrix that may not be well vascularized

A., Taher A

P62/Sequestosome-1 Up-Regulation Promotes Abt-263-Induced Caspase-8 Aggregation/Activation On The Autophagosome

Lancet 352 , 11721177 (1998)

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