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360 Additionally, studies have shown that the expression of PGC-1-responsive genes is downregulated in the brains of PD patients, possibly due to hypermethylation of PGC-1 transcriptional elements, leading to bioenergetic dysregulation

Enzyme proteins are proteins that help make biochemical reactions happen faster (such as by holding reactants together in the optimal positions, etc.) And metabolism refers to the making and breaking of biochemicals

Cochrane Handbook for Systematic Reviews of Interventions 4.2.5 [updated May 2005]

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These results demonstrate the promise of research on factors affecting GSH and therapeutic approaches to support its metabolism