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The impact of endotoxins and leaking antigens on detoxification mechanisms can be significant

The rapid success of SGLT2 inhibitors reflects not only their strong mechanistic rationale but also broad applicability across HF phenotypes and the advantage of testing within large cardiovascular outcome trials originally designed for diabetes

Subsequent research should focus on developing more potent ferroptosis inhibitors, aiming to advance these compounds into clinical trials

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Manufacturers must comply with relevant regulations to ensure that the products are not used for human treatment