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Current opinion in clinical nutrition and metabolic care' 2016 Nov Cristiana Paul, David M Brady

Association between metformin and vitamin B12 deficiency in patients with type 2 diabetes: A systematic review and meta-analysis

[9] Patients should be advised to contact their healthcare provider if they experience any severe or persistent side effects, such as difficulty breathing, chest tightness, severe rash, or dizziness

In laboratory testing, it did not inhibit related SAM-dependent methyltransferases or interfere with other enzymes in NAD+ salvage pathways

While the difference was considered statistically significant, it fell short of the goal set by the FDA for the approval of antiobesity drugs, which is a 5% weight loss beyond that achieved with placebo