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After internalization of the Tf-TfR1 complex into endosome, iron is released from Tf, and transferred to the cytosol by DMT1 to join the labile iron pool (LIP)

Alver BH, Kim KH, Lu P, Wang X, Manchester HE, Wang W, et al

In contrast to the conserved catalytic triad, the substrate binding site is variable, but includes hydrophobic residues inside a pocket of the central -sheet (Pleiss et al., 1998)

Single-cell and spatial analyses of cancer cells: toward elucidating the molecular mechanisms of clonal evolution and drug resistance acquisition

Proc Natl Acad Sci USA 118:37 Song E, Bartley C, Chow R, Ngo T, Jiang R, Zamecnik C, Dandekar R, McAlpine L, Spudich SS, DeRisi J, Iwasaki A (2021) Divergent and self-reactive immune responses in the CNS of COVID-19 patients