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The single pgdS gene knockout, as well as the double knockout of pgdS and ggt gene, resulted in a drastic reduction in PGA production, while the single ggt gene knockout improved PGA production due to lesser degradation (Ojima et al., 2019)

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However, some previous studies have shown that ferritinophagy can occur in cells lacking the LC3 lipidation machinery (ATG7), which would preclude membrane-facilitated multimerization of LC3 family proteins (Goodwin et al, 2017