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It also upregulates the expression of the gastrointestinal barrier proteins ZO-1 and occludin in MPTP-treated mice, improves intestinal barrier function and gastrointestinal dysfunction, and consequently exerts a neuroprotective effect indirectly via the gut-brain axis ( Another study demonstrated that administration of neohesperidin, the primary active component of citrus fruits (25 and 50 mg/kg, administered for 24 days), significantly alleviated MPTP-induced damage to dopaminergic neurons in the substantia nigra-striatal pathway of PD mice, increased levels of striatal dopamine (DA) and its metabolite DOPAC, and improved motor dysfunction

p62 is a versatile protein with crucial functions in cellular protein homeostasis through both autophagy and the proteasome

In addition, no evidence has been found that ingesting it orally produces the same benefits as taking it directly

Bromelain acted by removing the extracellular domains of the CD44, CD45RA, E2/MIC2, CD6, CD7, CD8, and Leu 8/LAM1 surface molecules and thus enhancing T cell activation through CD2

Resveratrol reduces the production of ROS through multiple mechanisms