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Concurrently, activation of MAPK (p38/JNK/ERK) activates AP-1, enhances mRNA stability, and promotes immune cell infiltration, all of which collectively orchestrate the inflammatory response [286,287,288]

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A reverse effect was observed with Cd and Pb in some plants

Weinstein G, Schonmann Y, Yeshua H, Zelber-Sagi S

Physical enhancement methods including iontophoresis, microneedling, and ultrasound also significantly increase GHK-Cu delivery, with microneedling pre-treatment increasing peptide penetration by approximately 10-fold compared to intact skin application, effects similar to those achieved with other topical peptide formulations optimized for transdermal delivery