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Rapid temperature changes may also place unnecessary stress on sensitive molecules

elegans and ameliorated mutiple aging-related phenotypes, including enhanced resistance to oxidative and thermal stress, improved motility, pharyngeal pumping, defecation rhythm, and reduced lipofuscin/lipid accumulation

Gut 56 , 6172 (2007)

However, its angiogenic properties which support blood vessel formationcould theoretically present risks in individuals with undiagnosed cancer or abnormal cell growth

Systematic dose reduction involves decreasing by one tier every 8 to 12 weeks while closely monitoring weight, appetite, and metabolic parameters