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214221, DOI:10.1007/s10787-006-1531-7

Its well known that cigarette smoking causes lung cancer, as well as 17 other types of cancer and many other chronic diseases, including cardiovascular disease and respiratory diseases

This process involves the activation of Rho GTPases and kinases that subsequently activate transcription factors

Br J Pharmacol (2009) 156(4):60925

This method is more realistic than rigid docking and has proven effective, particularly in HIV drug discovery efforts since the early 2000s
