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The decreased malate/pyruvate and GSH levels with LbNOX expression strongly suggest a decreased cytoplasmic (free) [NADPH]/[NADP + ], while the large increase in pyruvate also strongly suggests that the pyruvate/lactate, a proxy for the cytoplasmic (free) [NAD + ]/[NADH], increased, which likely drove the lifespan extension in the females

4.5.3.4 From correlation to causation Establishing causal linkage between amino acid metabolites and DKD necessitates integration of evidence from diverse research domains

Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck

When glucose starvation occurs, a large amount of NADPH is consumed, and the NADP+/NADPH ratio significantly increases
