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doi: 10.1073/pnas.1215689109

During vigorous muscle contraction or during fasting, ATP concentration decreases and AMP concentration increases leading to the activation of AMP-activated protein kinase (AMPK)

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It should be noted that in our study, there was an acute change in TMAO to reflect the cycling of TMAO concentration within the blood, whereas in other studies, more long-term treatment of TMAO has been used