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2026 Apr;652(8110):740-751
Rebouissou S, Nault JC (2020) Advances in molecular classification and precision oncology in hepatocellular carcinoma

It also reduces the secretion of transforming growth factor-beta1 in fibroblasts, an important step in countering the negative effects of DHT

Being synthesized by cells such as premature or mature osteoblasts, osteocytes, and osteoclasts, IGF-1 binds to cell surface receptors to stimulate the proliferation and differentiation of osteoblast precursors, thereby enhancing bone formation and maintaining bone mass and creating a bone microenvironment that caters to cancer cell growth (Figure 1) [78,79]

De Leo, A
