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Urgent medical attention is needed for inability to keep fluids down for more than 24 hours, signs of dehydration, or severe abdominal pain

[27] The Met20 loop of DHFR is able to open, close or occlude the active site

Recent attention has been drawn to the potential of dietary changes and antioxidant supplementation in reducing the harmful effects of pollution in healthy populations and in individuals with conditions like asthma and other chronic respiratory diseases (64)

There were no significant differences in race, age or sex between the patients with MASH and controls (Extended Data Fig

For metabolite extraction, 5 l of urine was transferred to a glass insert and extracted using 195 l of cold 80% methanol spiked with 500 nM metabolomics amino acid standard mix (Cambridge Isotopes Laboratory)