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The gut microbiome in atherosclerotic cardiovascular disease

Both local and systemic applications of yeast glucan significantly lower malondialdehyde (MDA, a final product of lipid peroxidation), maintain tissue glutathione (GSH) levels, and inhibit myeloperoxidase (MPO) activity in neutrophils, effectively protecting against oxidative damage

2025;77:551-567.[DOI] 74

Unlike the tetrameric GPx1-GPx3, the GPx4 protein is a monomer which can not only reduce hydrogen peroxide, but also distinctly react with lipid and fatty acid hydroperoxides including cholesterol derivatives, amongst many other substrates

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