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Beyond GSH metabolism, Nrf2 also promotes intracellular NADPH generation by upregulating the expression of genes related to the pentose phosphate pathway, which contains the key enzyme G6PD, as well as genes involved in pyruvate cycling and folate metabolism (166)

In conclusion, although ozone is not the only culprit for adverse health effects, it significantly contributes to exacerbate respiratory illnesses and enhances mortality in about 40% of the total US population [21]

X.et al (2024b)

doi: 10.3390/ijerph191811635

59 , 81 , 82 ATP depletion also affects the ability of the cell to maintain its shape and membrane integrity
