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Ultrasound Obstet Gynecol 2010

The proteasome recognizes and degrades ubiquitinated proteins
Only a few studies have investigated the mechanisms through which ferroptosis influences disease progression or affects clinical outcomes

1 Background Autoimmune thyroiditis (AITD) is a T-cell-mediated, organ-specific autoimmune disease that mainly manifests as Hashimotos thyroiditis (HT) and Graves disease (GD) (Antonelli et al., 2015)

In senescent cells, FOXO4 sequesters p53 in PML nuclear bodies, preventing p53-mediated apoptosis and allowing senescent cells to remain viable despite growth arrest
