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Ozono S, Zhang Y, Ode H, Sano K, Tan TS, Imai K, et al

Use of probiotics as food additives and its legal basis

Abbreviations TME: Tumor microenvironment ROS: Reactive Oxygen species NK cells: Natural killer cells DCs: Dendritic cells GLS: Glutaminase -KG: -Ketoglutarate TCA: Tricarboxylic acid cycle HIF: Hypoxia-inducible factor LDHA: Lactate dehydrogenase A GSH: Glutathione NADPH: Nicotinamide adenine dinucleotide phosphate NF-B: Nuclear factor-kappa B IFN-: -Interferon CAFs: Cancer-associated fibroblasts PBTLs: Peripheral blood T lymphocytes SERCA: Sarcoplasmic reticulum Ca 2 + -ATPase Th1: CD4 + T helper 1 Th2: CD4 + T helper 2 Treg: Regulator T Th17: CD4 + T helper 17 SLC1A5: Solute carrier family 1 neutral amino acid transporter member 5 ASCT2: Alanine, serine, cysteine-preferring transporter 2 SLC7A5: Solute carrier family 7, member 5 SNAT: Sodium-coupled neutral amino acid transporter LPS: Lipopolysaccharide TAMs: Tumor-associated macrophages GS: Glutamine synthase HBP: Hexosamine biosynthetic pathway TANs: Tumor-associated neutrophils NETs: Neutrophil extracellular traps L-DON: 6-Diazo-5-oxo-L-norleucine AMPK: AMP kinase TILs: CD8 + tumor-infiltrating lymphocytes OXPHOS: Oxidative phosphorylation MDSCs: Myeloid-derived suppressor cells ECM: Extracellular matrix GFPT1: Glutamine-fructose aminotransferase 1 CTLs: Cytotoxic T lymphocytes CAR: Chimeric antigen receptor TNBC: Triple-negative breast cancer B7H3: B7 homology 3 References Hanahan D, Weinberg RA

10.1136/heartjnl-2019-315485 100 SongT

For the kidney, degeneration of glomerular structure and dilatation of Bowmans space, degeneration of proximal and distal tubule, vascular congestion and inflammatory cell infiltration were taken into consideration