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Patients either received 15 mg twice-daily IN-NAP or placebo for a period of 12 weeks, with limited adverse events noted (i.e., headache) and a cognitive battery carried out at baseline and after 4, 8, 12, and 16 weeks of IN treatment [108,109]
Age at baseline and sex were included as fixed effects in the LMMs and individual and study centre were included as random effects, with individual nested under the study centre
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The use of omics technologies and bioinformatics further accelerates the discovery and development of new drugs (Li and Zhang, 2013)
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