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We hypothesize that the influence of SFN on the gut microbiota is at least partly related to the effects on their habitat, i.e., the gut such as (i) alleviation of oxidative stress and inflammation in the intestine, (ii) increase of the expression of tight junction proteins, preventing excessive intestinal permeability and invasion of luminal bacteria, and (iii) promotion of gut detoxification capability via increase of activity of phase II detoxification enzymes such as GSTs

Glucose can undergo non-enzymatic reactions to form gluco-oxidants and glycated products, which can be oxidants [13]

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In chromosome 3 and 4 has eleven genes each, while chromosome 5 and 8 have seven genes each

The corresponding energy deficiencies due to mitochondrial dysfunction amplify oxidative stress via the release of more oxygen radicals into the CNS [204]