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PD-1 and its ligands in tolerance and immunity

Some clinical isolates from patients with head and neck cancer exhibit moderate to high fluconazole tolerance, with high-tolerance strains upregulating ERG11 , CDR1 and other genes to maintain biofilm integrity and drug survival under antifungal pressure (Hatami et al., 2023)

Later work from the same group using o -phenylenediamine as a trapping agent suggested that a thiirane [2,2-difluoro-3-chlorothiane] was a likely intermediate in the decomposition of 1,1-difluoro-2-bromo-2-chloroethanethiolate (Anders, 2008, Finkelstein et al., 1996)

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It achieves these effects by promoting fibroblast proliferation, a process vital for wound healing [2, 3, 6]