activates lipoprotein lipase lpl apo c-i1 xmlinkhub The regulation of LPL by
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These mutations lead to inadequate levels of the enzyme, very long-chain acyl-coenzyme A dehydrogenase resulting in the accumulation of long-chain fatty acids and patients are unable to make ketone bodies for energy
At the central level, the impaired mitochondria reduce the glucose uptake and ATP production in the brain, which subsequently hinders the energy balance

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Taguchi et al
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