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Thus, ROS and NOS (and their metabolic intermediates with high reduction potential) are elevated proportionally to the concentration of excess O 2 and should be importantly considered as inducers of pulmonary oxidative damage during hyperoxia [60,274,275,276] as they sustain oxidative stress, perpetuate lung inflammation, and induce apoptosis as well as necrosis [277,278,279,280,281]

ALCAR alters the rate of glucose utilization in brain Aureli et al

Rashidi, M

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For AD, we specifically used two recently published GWAS data, one from the International Genomics of Alzheimers Project (IGAP) (21,982 cases and 41,944 controls), and the other from a large meta-analysis (71,880 cases and 383,378 controls) as validation data